Single Cell Genomics

Generally, genome research is based on the results obtained from the analysis of nucleic acid samples from a number of cells in each individual. It is already well known that the genetic information of each cell is not the same, even if it is a sample obtained from the tissue of the same individual. A common genome research method is to identify the average results of cells with numurous different genetic information (Somatic Mutation, Gene Expression, etc.), and the average information contains fundamental errors because it does not reflect the actual values as they are. In order to overcome this problem, the need for single cell research has been greatly increased for several years. However, the method of isolating single cells was so difficult that it was not easily accessible, and even if a device that automatically separates a single cell was released, it was difficult to try because of the small number of cells to be treated, the limitation on cell size and shape, and too expensive experiment cost. Recently, devices that can be applied to various NGS applications by separating thousands of single cells regardless of cell size or species were released, attracting a great deal of attention from researchers with a need for single cell research.

As the need for single-cell research is growing, reagents incorporating new techniques that amplify small amounts of sample to ensure reliable use in subsequent studies without errors for the genetic information have been released. Single-cell genome analysis technology is expected to be actively used to identify new disease mechanisms and develop new drugs.

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